To investigate how IFNγ and TGFβ affect CCKAR and collagen expression in the presence of TILs, we cocultured tumor cells with autologous control TILs or attIL12-TILs with or without additional IFNγ, TGFβ, or their neutralizing antibodies (Fig. 6C). This evidence concerns the gene TGFB1 and neoplasm.