IFNG and neoplasm: We therefore hypothesized that attIL12-transduced TILs synergize two pathways of IFNγ production by enabling the simultaneous interactions of the TCR on TILs and human leukocyte antigen (HLA) on tumor cells and between attIL12 and CSV, destroying the collagen barrier around tumors and opening a channel for T cells to infiltrate and kill tumor cells.