High CCKAR expression in the tumor cells amplified pAKT-induced collagen expression even after attIL12-TIL coculture, suggesting that under low levels of TGFβ and pSMAD3 activation, constitutive expression of CCKAR functions as a robust inducer of AKT signaling and in turn promotes collagen expression in sarcoma cells. This evidence concerns the gene TGFB1 and sarcoma.