ADH1B and lung cancer: Ding et al. (73) in a two sample design using ADH1B rs1229984 as IV in 2,485 lung cancer cases and 410,350 controls of European ancestry showed no causal relationship between habitual alcohol intake and lung cancer [OR = 1.30 (0.39–4.35), p = 0.674], authors suggest that this may be due to the use of only 1 genetic variant, resulting in insufficient statistical power.