Regarding ischemic heart disease, a one-sample MR study using 8,408 cases from using the China Kadoorie Biobank found no association with mean alcohol intake instrumented by ALDH2-rs671 and ADH1B-rs1229984 [HR per 280 g per week = 1.04 (0.94–1.14), p = 0.457] (71). The gene discussed is ADH1B; the disease is coronary artery disorder.