Deng et al. (82), in a one-sample MR design using data from Biobank Japan (1,866 cases; 195,745 controls) performed on Asian population, reported a significant positive association between alcohol consumption, instrumented by ADH1B rs1229984 and ALDH2 rs671, and HCC risk [OR = 1.57 (1.32–1.86), p < 0.001]. This evidence concerns the gene ALDH2 and hepatocellular carcinoma.