ALDH2 and atrial fibrillation: Another one-sample MR study using 8,964 Asian participants genotyped for the ALDH2-rs671 SNP found a significant association with AF in men but not in women [OR = 3.00 (1.13–8.68)] and multivariate model [OR = 3.17 (1.18–9.24)] (109), conversely to their observational analysis.