EDAR and neoplasm: By contrast, esg>GFP+ cells in Dl RNAi guts formed ISC-like tumor clusters that were negative for Su(H)-lacZ (Figure 1D–D” and F), similar to the ISC-like tumor clusters in guts containing Dl or N mutant clones (Micchelli and Perrimon 2006; Ohlstein and Spradling 2006; Ohlstein and Spradling 2007; Siudeja et al. 2015), suggesting that in Dl RNAi guts, N pathway activity was diminished.