The most significant genomic risk locus of LBA indicated the WNT16 gene in chromosome 7 which has previously been linked to reduced cortical volume in Alzheimer patients (Dong et al., 2023) and has also been implicated in other age-related traits like brain age (Kim et al., 2023) and osteoporosis (Guindo-Martínez et al., 2021). Here, WNT16 is linked to osteoporosis.