The-3-fold increase in TRPV4 transcription and responsiveness to GSK101, observed at POAG-relevant TGFβ2 concentrations (In AH ~0.2-3.2 ng/ml; 20) showed a time course that mirrored facility reduction in human eyes treated with exogenous cytokine (105). This evidence concerns the gene TRPV4 and open-angle glaucoma.