TGFB2 and open-angle glaucoma: TGFβ2-induced fibrotic remodeling has been linked to POAG: (i) TM cells derived from POAG patients secrete more active TGFβ2 compared to cells isolated from healthy donors (19), (ii) the risk of POAG is proportional to [TGFβ2]AH (20-22), and (iii) ectopic ocular expression of TGFβ2 suffices to induce OHT (23, 24), likely via aberrant secretion of ECM proteins and enhanced TM contractility (25, 26).