SDHB and neoplasm: Of note, these responses were seen in patients with paraganglioma syndrome type 4 (SDHB).40 In addition, impressive PRs were detected in patients with VHL disease, MEN2, and several apparently sporadic tumors.40 The ORR was 38% and the disease control rate was 83%.40 These favorable tumor responses were associated with improvement in catecholamine concentrations compared with baseline, and 70% of patients discontinued antihypertensives.40 Many of these patients later achieved durable therapeutic responses.