Alkaline phosphatase is known for its role in bone health, but it is also implicated in various inflammatory conditions such as atherosclerosis.11 Recent studies have highlighted the involvement of AP in anti-inflammatory processes through its ectonucleotidase activity, which converts proinflammatory ATP into the anti-inflammatory nucleotide adenosine.17,31,32 Thus, elevated AP levels in warm CRPS may reflect a combination of increased bone remodelling and (anti-)inflammatory processes characteristic of this subtype. Here, DHCR7-DT is linked to complex regional pain syndrome.