The findings of this study suggest that CES1 may enhance cisplatin efflux from HNSCC cells by up-regulating, ABCB1, ABCC1, ABCG2, ATP7A, and ATP7B, leading to reduced intracellular cisplatin levels and ultimately promoting cisplatin resistance in HNSCC. The gene discussed is ABCB1; the disease is head and neck squamous cell carcinoma.