Abca1 and Abcg1 knockout animals in dendritic cells exhibit a SLE-like pattern of adenomegaly and glomerulonephritis, with cellular cholesterol accumulation and activation of proinflammatory pathways, linking to polarization towards T helper lymphocytes 1 (Th1) and Th17, and more M1-inflammatory macrophages. Here, ABCA1 is linked to systemic lupus erythematosus.