Premenopausal women with CT-induced menopause treated with gonadotropin-releasing hormone (GnRH) agonists, women initially treated with tamoxifen (TAM) and then treated with AI, and ultimately women treated alone with AI, particularly those aged 70 years, had the highest risk of osteoporosis [131, 132]. This evidence concerns the gene GNRH1 and osteoporosis.