Developmental delay and intellectual disability have also been reported in some individuals with plasminogen deficiency.10,20 Further studies will be necessary to determine whether cognitive impairment is a cardinal feature of tPA and plasminogen deficiencies and whether it is secondary to hydrocephalus or is caused by the disruption of specific neuro-developmental processes involving plasmin-dependent or independent mechanisms. The gene discussed is PLG; the disease is Cognitive impairment.