Interestingly, subependymal heterotopias have also been reported in an individual with plasminogen deficiency.19 The observation of neuronal migration defects in patients with either tPA or plasminogen deficiency is consistent with the suggestion that these proteins influence neuronal migration by activating plasmin to break down cell adhesions or extracellular matrix.18 Cognitive deficits were observed in Individuals 1.1, 2.2 and 3.1. Here, PLG is linked to Cognitive impairment.