SOCS2 protein, as a major negative regulator, plays an important role in the carcinogenesis of various tumors by regulating cytokine signaling through the JAK/STAT axis.[25] In HCC, downregulation of SOCS2 is associated with tumor progression and poor prognosis.[25] Our RNA‐seq analysis confirmed that miR‐500a‐3p overexpression in HSCs activated the JAK/STAT pathway, while further mRNA and protein analysis indicated that SOCS2 downregulation led to significantly enhanced activity of JAK3, STAT5A, STAT5B, and p‐STAT5. This evidence concerns the gene SOAT1 and hepatocellular carcinoma.