STAT5B and Cirrhosis: highlighted the integral role of HSCs in promoting HCC progression, partly through their immune regulatory activities.[14] STAT5 expression was significantly and positively correlated with T‐cell enrichment, cytolytic activity, and PD‐L1 expression in HCC.[16] In addition, we found a close relationship between miR‐500a‐3p and PD‐L1 expression in cirrhosis tissues (Figure S3D, Supporting Information), suggesting that miR‐500a‐3p may play a role in the immune TME of HCC.