JAK3 and hepatocellular carcinoma: SOCS2 protein, as a major negative regulator, plays an important role in the carcinogenesis of various tumors by regulating cytokine signaling through the JAK/STAT axis.[25] In HCC, downregulation of SOCS2 is associated with tumor progression and poor prognosis.[25] Our RNA‐seq analysis confirmed that miR‐500a‐3p overexpression in HSCs activated the JAK/STAT pathway, while further mRNA and protein analysis indicated that SOCS2 downregulation led to significantly enhanced activity of JAK3, STAT5A, STAT5B, and p‐STAT5.