The PD‐1/PD‐L1 signaling pathway is a key mechanism of tumor immune evasion, in which PD‐L1 binding to PD‐1 leads to inhibition of T‐cell proliferation and cytokine secretion, as well as induction of T‐cell apoptosis and exhaustion.[30] This finding further underscores the immunosuppressive role of miR‐500a‐3p in the HCC microenvironment. The gene discussed is CD274; the disease is hepatocellular carcinoma.