For instance, bladder cancer was found to induce fibroblasts to differentiate into tumor‐associated fibroblasts through exosomes, resulting in elevated IL‐6 secretion.[23] Similarly, a recent study found that gastric cancer transmits miR‐27a to fibroblasts through exosomes to transform them into tumor‐associated fibroblasts, thus promoting gastric cancer growth and metastasis.[24] In the context of HCC, our study revealed that exogenous miR‐500a‐3p and HCC‐derived exosomal miR‐500a‐3p promoted HSC proliferation, migration, and activation. Here, IL6 is linked to hepatocellular carcinoma.