IHC analysis of the in situ HCC tissues demonstrated significant enhancement in SOCS2, STAT5A, STAT5B, α‐SMA, FAP, Ki‐67, and PD‐L1 in specimens with higher miR‐500a‐3p expression and suppression in specimens with lower miR‐500a‐3p expression, while the IHC expression of SOCS2 showed an opposite trend (Figure 6L; Figure S5B, Supporting Information). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.