Several studies have confirmed that γδ T cells play a critical role in tumor immunity by providing an early source of IFN‐γ.[2, 3] In fact, adoptive transfer of in vitro expanded human Vδ2 γδ T cells has shown promising clinical safety and efficacy.[35] However, the detailed molecular mechanisms responsible for IFN‐γ production and negative regulation of γδ T cells leading to tumor evasion are not fully understood. This evidence concerns the gene IFNG and neoplasm.