ALDH1A1 and Parkinson disease: Moreover, we have reported that DOPAL elevation activates AEP and triggers DA neuronal death in PD.[18, 34] Interestingly, DOPAL triggers α‐Syn aggregation and neurotoxicity via aldehyde covalent adducts.[35] In contrast, ALDH1A1 overexpression preferentially protects against α‐Syn–mediated DA neurodegeneration but does not alleviate cortical neuronal death.[5a] Again, these results are consistent with our findings with AEP‐resistant Sox6 N336/446A and ALDH1A1 N220A mutants (Figure 6).