It is essential for maintaining the dopaminergic phenotype, and disruption of its activity leads to DA neuron degeneration.[13] Satb1 and Sox6 are co‐expressed in DA neurons in the SNpc.[22] Interestingly, GEO DataSet re‐analysis showed that satb1 mRNA was significantly reduced in both the lateral and medial SN regions in PD, fitting with Sox6 mRNA levels (Figure S6I–K, Supporting Information).[23] Consequently, deletion of Sox6 in SH‐SY5Y cells evidently repressed both Satb1 and cytochrome c oxidase IV (COX IV) expression (Figure S6L–N, Supporting Information). This evidence concerns the gene COX4I1 and Parkinson disease.