TTN and familial dilated cardiomyopathy: These genes underscore the role of the contractile apparatus in DCM pathogenesis42, through known cardiac sarcomeric genes (for example, TTN, OBSCN and ACTN2), but also lesser-described structural genes including SVIL (encoding an actin-binding protein recently implicated in HCM19) and PDLIM5 (encoding a cytoskeletal linker43).