Several fine-mapped coding variants were found within known DCM genes (FLNC, BAG3 and TTN) and genes with plausible effects on cardiac function (NEXN and MYBPC3), including deleterious missense variants (combined annotation-dependent depletion Phred score >15) in TTN, BAG3 and MYBPC3. Here, FLNC is linked to familial dilated cardiomyopathy.