PTVs in membrane receptor regulator NEDD4L were associated with DCM (OR = 10.4, Padj = 0.01) P and with quantitative traits in UKB (PTV: LVEDV = +29.7, Padj = 0.02; LVESV = +19.8, Padj = 0.005), with replication in GeL (heart failure OR = 13.0, P = 0.01). The gene discussed is NEDD4L; the disease is heart failure.