Genes associated with Mendelian forms of hypertrophic cardiomyopathy (HCM) (MYBPC3, ALPK3 and FHOD3) were also identified at genomic risk loci for DCM, a finding consistent with evidence that these disorders represent opposing extremes of a continuum of ventricular structure and systolic function9,11. Here, ALPK3 is linked to hypertrophic cardiomyopathy.