ACTN2 and cardiomyopathy: Within the identified DCM loci were seven Mendelian cardiomyopathy genes cataloged in ClinGen, a curated database of Mendelian-disease causing genes, with definitive evidence (DCM: TTN, FLNC, LMNA, BAG3; HCM: MYBPC3, ALPK3, FHOD3) and seven genes with moderate or limited evidence (DCM: PRDM16, LDB3; DCM or HCM: OBSCN, VCL, NEXN, MYPN; intrinsic cardiomyopathy: ACTN2).