Regarding the main function of Th2 cells, it is to regulate humoral immunity via secreting IL-4, it is worth noting that, however, excessive secretion of IL-4 can contribute to the production of a large amount of specific IgE and the aggregation of eosinophil aggregation in the airway, leading to airway hyperresponsiveness and even irreversible tissue damage29–31. The gene discussed is IL4; the disease is airway hyperresponsiveness.