While we are well aware of the caveats inherent to any LOF/GOF experiments, we consider that the depletion/overexpression approach used in this study is of clear physiological relevance, since the magnitude of the changes in EpCAM and Trop2 levels is compatible with what happens during cancer development, including the abrupt drop in EpCAM expression observed after EMT (Sankpal et al, 2017). Here, EPCAM is linked to cancer.