Therefore, 11 insulin-responsive cell lines were screened for insulin-induced EphA2 regulation, including four hepatoma (HepG2 WT, HepG2 IGF1R KO, Hep3B, and H4IIE), three acute myeloid leukemia (AML) (MOLM-13, THP1, and EOL-1), and four breast cancer cell lines (BT549, BT474, HCC38, and HCC1937). The gene discussed is INS; the disease is acute myeloid leukemia.