Intratumor bacterial therapy could modulate the physical and chemical cues of tumor tissues, including normalizing tumor vasculatures and elevating the concentration of a series of T-cell centered chemokines including CCL3, CCL4, and CCL5 (Fig. 1a).27–30 These chemokines play crucial roles in recruiting and activating immune cells within the tumor microenvironment. This evidence concerns the gene CCL3 and neoplasm.