The IMF model frequently selected features with interactions between p53 signaling genetic status (as well as MGMT for TMZ) and apoptotic potential (Supplementary Fig. 5A) and predicted GBM sensitivity values for IR + BCL-XLi (r2 = 0.74, RMSE (Root Mean Square Error) = 15.36) and TMZ + BCL-XLi (r2 = 0.64, RMSE = 14.69) (Fig. 5B, Supplementary Fig. 6A). This evidence concerns the gene TP53 and glioblastoma.