IL18 and neoplasm: The elevated cytokines include those involved in direct tumor cell killing (TNF, TNFR, IFN-γ, Fas ligand); granzymes secreted immune cells (GZMA, GZMH, and GZMB), chemokines that promote cell recruitment and activation (CXCL9, CXCL10, CXCL11, CXCL13, CCL19, and CCL23); and interleukins regulating immune cell function (IL-12, IL-18, and IL-10).