Hye and colleagues later identified 10 plasma proteins using multiplex bead assays (Luminex xMAP), clusterin, transthyretin, cystatin C, A1AcidG, intercellular adhesion molecule 1 (ICAM1), complement C4, pigment epithelium‐derived factor (PEDF), A1AT, RANTES, apolipoprotein C3 (ApoC3), which significantly differentiated subjects with AD from those with MCI and elderly subjects without dementia (n = 1148) with a high degree of diagnostic accuracy (87% accuracy, 85 sensitivity, 88% specificity).79 This evidence concerns the gene CLU and Alzheimer disease.