A serum‐based panel with six proteins—inter‐alpha‐trypsin inhibitor heavy chain H4 (ITI‐H4), ApoA4, Cofilin 2, Tetranectin, Zinc‐alpha‐2‐glycoprotein (AZGP1), and alpha‐1‐microglobulin/bikunin precursor (AMBP)—were altered that was identified in AD patients.90 This evidence concerns the gene APOA4 and Alzheimer disease.