Villarreal and colleagues identified two serum‐based proteins, IL‐18 and T‐lymphocyte‐secreted protein (TLSP), which differentiated subjects with AD from control subjects with AUC of 0.94 (86% sensitivity, 90% specificity) in a cohort with 135 participants: the level of IL‐18 was significantly elevated but TLSP was deceased in the former.88 The gene discussed is IL18; the disease is Alzheimer disease.