The events that upregulate NLRP3 in AD include increased levels of the danger‐associated molecular patterns (DAMPs) such as adenosine triphosphate, reactive oxygen species, and cathepsin B (Savage et al., 2012), which activate nuclear factor kappa B through toll‐like receptors (Yang et al., 2020). The gene discussed is CTSB; the disease is Alzheimer disease.