The nonagenarians showed significantly lower p-tau181 levels (P=0.001) and higher Aß42 (P<0.001), Aß40 (P<0.001), Aß42/40 ratio (P=0.023), total tau (P=0.02) and NfL (P=0.001) than AD cases. The gene discussed is NEFL; the disease is Alzheimer disease.