GPX4 and psoriasis: To better delineate the role of K14+ KC ferroptosis in psoriasis, we generated a tamoxifen-inducible (TMX-inducible) genetic mouse model, K14-CreERT+/+ Gpx4fl/fl (referred to henceforth as K14/Gpx4), with Gpx4 depletion in K14-expressing KCs (Figure 3A and Supplemental Figure 6, A–F).