Analyses of the skin of K14/Gpx4 mice revealed parakeratosis and acanthosis with elevated epidermal proliferation index, mixed dermal immune cell infiltrate including T lymphocytes, clusters of neutrophils in the epidermis, and upregulation of psoriasis-associated cytokines and lipid mediators (Figure 4, F–I, and Supplemental Figure 8, E and F). Here, KRT14 is linked to psoriasis.