We also compared how the K14/Gpx4 model recapitulates the gene expression pattern of psoriasis relative to published studies of human disease (18, 32), and relative to other mouse models of psoriasis: topical imiquimod (IMQ) (33, 34), K14-AREG (35, 36), K5-Stat3C (36, 37), and intradermal IL-23 (idIL-23) (38, 39), which vary in their transcriptional similarities to psoriasis (Supplemental Figure 9, A and B, and Supplemental Table 9) (36). This evidence concerns the gene GPX4 and psoriasis.