More specifically, we show that the K14/Gpx4 model, which enforces psoriasis-associated sporadic pro-ferroptotic phospholipid peroxidation in a relatively small fraction of KCs, recapitulates most of the phenotypic, immunological, and multiomic hallmarks of psoriasis, including an effective response to current standard biological therapies. This evidence concerns the gene KRT14 and psoriasis.