We reasoned that this may be because of indiscriminate pro-ferroptotic activities of topical RSL3 and erastin on the KCs as well as immune and other types of skin cells, and while these agents increase pro-ferroptotic oxPE in the skin, they cannot fully recapitulate other elements of psoriasis such as KC proliferation and IL-23/Th17 inflammation. Here, TBCE is linked to psoriasis.