Our analysis revealed the upregulation of 3 ferroptosis markers (Chac1, Slc40a1, Fth1) and 29 ferroptosis drivers (including Alox12B and Alox15B, which encodes 15-LOX-2) as well as downregulation of 7 ferroptosis suppressors in psoriasis (Supplemental Table 2 and Figure 1B). The gene discussed is CHAC1; the disease is psoriasis.