TNK2 and systemic lupus erythematosus: However, we analyzed 27 GWAS studies of SLE (https://www.gwascentral.org/), and none of them reported a common variant within close genetic distance of the TNK2/ACK1 or PTK6/BRK genes with a p-value lower than 5x10–8, a statistical threshold of genome-wide significance for GWAS.