DNASE1L3 and systemic lupus erythematosus: The contribution of genetics to SLE is supported by epidemiological data showing familial aggregation (Arnett and Shulman, 1976; Alarcón-Segovia et al., 2005; Reichlin et al., 1992) and higher concordance rates between monozygotic than dizygotic twins (Deapen et al., 1992), the association of autosomal recessive deficiency in PKCdelta or DNAse1L3 with familial SLE, and similar phenotypes in the corresponding mouse models (Belot et al., 2013; Kiykim et al., 2015; Salzer et al., 2013; Al Mayouf et al., 2011; Ozçakar et al., 2013; Sisirak et al., 2016).