ESR1 and neoplasm: Of these features, stage II was the most common cancer stage (67.5%), node status was N0 (34.4%), cancer grade was grade II (71.2%), tumor size was ≥ 2–5 cm (74.2%), NPI was > 3.4–5.4 (MPI, 74.2%), positive ER was (79.8%), positive PR was (76.1%), negative Her2/neu expression was (54.6%), negative metastasis was (85.3%) and left operated breast was (61.4%), and age over 50 years was (55.2%).