TNF and breast cancer: In the dominant TNF-α−308G > A model the GG genotype versus those with (AA + GA genotypes), there was a strong significant risk factor for A allele in both the BC and BBI groups (P < 0.0001) in terms of quantity of cases in total in contrast to their respective controls and a significant risk factor to A allele in the BC in comparison to the BBI groups (P = 0.043), [ORs (95% CI) were 10.77 (6.17–18.79), 5.59 (3.01–10.36), and 0.52 (0.26–1.02), respectively].