PTPN11 and juvenile myelomonocytic leukemia: Neurobiological studies have been performed in mice expressing several PTPN11 variants, including PTPN11D61G and PTPN11N308D, which are associated with NS and PTPN11D61Y, which occurs as a somatic mutation in humans and leads to juvenile myelomonocytic leukaemia (JMML) (Tartaglia et al. 2003; Lee et al. 2014; Altmüller et al. 2017; Ryu et al. 2019).