CAPN8 and cancer: Recently, Capn8 has been implicated in EMT associated with cancer metastasis (Zhong et al., 2022; Song et al., 2024) and Xenopus capn8 was found to be required for cranial NCC migration (Cousin et al., 2011) which further supports a role of capn8 in cranial NCC migration and craniofacial morphogenesis.