Obesity promotes IL-33 signalling and improves mild inflammation while increasing cardiovascular risk, a phenomenon that could be referred to as the “obesity paradox.” The role of ghrelin in cardiac remodelling and its association with the IL-33/ST2 pathway has been proposed, but further experiments involving ghrelin inhibitors are needed to fully investigate its role (Ref. The gene discussed is GHRL; the disease is obesity due to melanocortin 4 receptor deficiency.