α‐CD is derived from starch and is widely used in the food industry, where it enhances the flavor and stability of various food products.[56] In addition, α‐CD, as one kind of resistant starch, has been shown to modify gut microbiota, reduce fat accumulation in high fat diet‐fed obese mice and prevent atherosclerosis of ApoE deficient mice,[57, 58, 59] Overall suggesting α‐CD as a safe and effective supplement in combating obesity and aging associated metabolic diseases. This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.