TNF and psoriasis: Topical corticosteroids, keratolytics, vitamin D analogs, and topical calcineurin inhibitors are the conventional first-line therapy for mild psoriasis [4]. In the last 15 years, advances in understanding the pathogenesis of psoriasis have translated into targeted and highly effective therapies using biological treatments, the main ones with real-world clinical experience being antibodies against tumor necrosis factor-alpha (TNF-α), and interleukins (IL) 12, 17, 21, and 23 [5].