APC and neoplasm: On the contrary, for tumor grade, in low-grade tumors, the distribution was even between methylation and unmethylation of the APC promoter with 16 (47.1%) and 13 (81.3%) respectively, but in the case of high-grade tumors, methylation was a little higher occurring in 18 (52.9%) of cases and with a p-value of 0.