The same deduction was made by Berrada et al. on APC promoter methylation, showing that it presented an aberrant methylation regardless of clinicopathological features of BLCA patients and its frequency was 100% in all the cases studied, suggesting a very high biomarker value for the diagnosis of BLCA in its early stages since the hypermethylation was observed in all stages and grades of cancer [24]. Here, APC is linked to cancer.