For example, miR-342-5p was found to suppress PI3K/AKT in classically active macrophages and act anti-inflammatory in an atherosclerosis plaque mouse model (32), and in an acute kidney injury model, exosomes loaded with miR-342-5p alleviated inflammation by targeting TLR9 to promote autophagy (33). This evidence concerns the gene TLR9 and atherosclerosis.