According to the Kaplan-Meier (KM) survival analysis of 8 modeled genes, elevated expression levels of COL5A2, COX6A2, UQCRB, SFXN4, FAM162A and MAFF sharply shortened the survival time of osteosarcoma patients (Supplementary Figures S1A–H). The gene discussed is COL5A2; the disease is osteosarcoma.