According to the Kaplan-Meier (KM) survival analysis of 8 modeled genes, elevated expression levels of COL5A2, COX6A2, UQCRB, SFXN4, FAM162A and MAFF sharply shortened the survival time of osteosarcoma patients (Supplementary Figures S1A–H). This evidence concerns the gene SFXN4 and osteosarcoma.