Because this was the first exposure to HSV-2, we did not examine the antigen specific responses, rather we would posit that the enriched proportion of IFN-γ producing T cells in the vaginal tract and spleen in response to NET-EN treatment would assist in rapid primary response to viral infection, since IFN-γ has been shown to be the main correlate of protection from HSV-2 (28–30). The gene discussed is IFNG; the disease is viral infectious disease.