In turn, one could follow up in future study designs to investigate how workaholism is promoting excess nutrient overload that is a major driver of impaired hepatic glucose production, skeletal muscle insulin resistance, development of systemic inflammation, and destruction of insulin-secreting pancreatic β-cells, which all contribute toward the pathogenesis of cardiovascular diseases and T2D (DeFronzo and Tripathy, 2009; Petersen et al., 2017; Ying et al., 2020). Here, INS is linked to cardiovascular disorder.