Second, the contribution of synaptic inputs on the neuronal excitability of pyramidal neurons in the PFC, and the impact of diminished activity-dependent BDNF signaling on the principle neurons in the other brain regions, need to be further investigated, which may mediate the anxiety, autism-like social deficits, and sex-specific effect of diminished activity-dependent BDNF signaling on spatial memory (Ma et al., 2023). The gene discussed is BDNF; the disease is Anxiety.