Their anti-metastatic properties can be attributed to various factors, including inhibition of the heparanase enzyme, mainly involved in cancer progression; inhibition of angiogenesis, lymphogenesis, and P-selectin-mediated platelets-cancer cell adhesion (96), Additionally, heparanase may enhance the recognition of the cancer cell by NK cells and enhance cancer clearance (25). The gene discussed is SELP; the disease is cancer.