GPX4 and cancer: It was reported that inactivation of neurofibromin 2 renders cancer cells susceptible to ferroptosis through inhibiting YAP/TAZ signaling, whereas activation of epidermal growth factor receptor (EGFR) and isocitrate dehydrogenase 1 promote ferroptosis by inhibiting SLC7A11 and GPX4, respectively.159, 160, 161