Attenuates the Severity of MASH; attenuates hepatic I/R injury and lipid peroxidation; improves inflammation and sickness behavior in aged mice treated with LPS; prevents vasoregression and microglia activation while improving AQP4 polarity as well as blood‐brain barrier permeability; reduce the area of cerebral infarction, improve the pathological structure of cerebral ischemia rats. The gene discussed is AQP4; the disease is brain ischemia.