HLA-C and psoriasis: Out of those, the fifth module encompassing the PSORS1 locus was associated with increased psoriasis (log (OR) (95% CI): 0.421 (0.393–0.450); p-value = 3.4 × 10−187), displaying the highest discriminative ability (c-statistic (95% CI): 0.613 (0.604–0.622) including 36,463 SNPs compared to all modules.