Studies from the field of Diabetes Mellitus (DM) directly link NLRP3 and CGRP-related pathways, where NLRP3 activation (e.g., via reactive oxygen species) and consequent IL-1β production have been shown to affect receptor resistance and apoptosis in DM models (Guo et al., 2015). The gene discussed is IL1B; the disease is diabetes mellitus.