SAND are defined by aggregates of abnormally misfolded α-synuclein (α-syn) in the peripheral and central nervous systems, which cumulatively refer to Parkinson’s disease (PD), Lewy body degeneration (LBD), and multiple system atrophy (MSA) pathologies (Lim et al., 2016). The gene discussed is SNCA; the disease is multiple system atrophy.