IL1B and atherosclerosis: The study of Xu et al. demonstrated that Puerarin-Tanshinone IIA (Pue-Tan) inhibits the formation of atherosclerotic inflammatory plaques and slows the progression of atherosclerosis by targeting the succinic acid/HIF-1α/IL-1β axis, lowering interleukin-1β (IL-1β) levels and interfering with succinic acid.