The cells show high proliferation activity with Ki67, which ranges from 15-60%.3,4 Additionally, Fatty Acid Synthase (FASN) expression aids in distinguishing oral melanomas from oral melanocytic nevi, as it demonstrates robust expression in mucosal surface melanomas.11 The similar color of melanin and commonly used chromogens create difficulty in interpretating IHC in cases of heavily pigmented lesions. This evidence concerns the gene MKI67 and melanoma.