NOTCH1 and myocardial infarction: Emerging evidence positions Notch1 signaling protects the heart from damage, effective in combating heart disease, heart attacks, abnormal growth, and injury from restored blood flow (Meester et al., 2019; Feng et al., 2023), as activation of Notch signaling effectively mitigates ischemic injury, protects cardiomyocytes from apoptosis, and regulates cardiac self-repair after myocardial infarction.