NR4A1 and bone cancer: In addition, inflammation increases the expression of NGFI-A in the anterior cingulate cortex in the wild-type mice.29 NGFI-B antagonists improve pain intensity in mice models of neuropathic pain and bone cancer, so reducing NGFI-B could have analgesic effects.30 In the current study, the administration of 10 and 20 mg/kg DMI before formalin injection eliminated formalin-induced NGFI-A and NGFI-B expression in the spinal cord.