Among these genes, we identified FGF19, downregulated in all three datasets, which is known to promote epithelial-mesenchymal transition (EMT) and self-renewal capacity of cancer stem cells, and to induce cell cycle arrest in differentiated chondrocytes (Wang et al., 2021; Zhao et al., 2016; Chen et al., 2023). This evidence concerns the gene FGF19 and cancer.