CV, cardiovascular; MI, myocardial infarction; MACE, major adverse cardiovascular events; CKD, chronic kidney disease; HF, heart failure; MASLD, metabolic dysfunction-associated steatotic liver disease; DKD, diabetic kidney disease; GLP-1 RAs, glucagon-like peptide-1 receptor agonists. The gene discussed is GCG; the disease is diabetic kidney disease.