In the univariate analysis, several factors, including sex, age, MAP, respiratory rate, HR, fibrinogen, PLT, WBC, Cr, PT, PTT, INR, ALB, LAC, MI, CHF, CKD, cancer, liver disease, MST, SOFA, APS III, CCI, MV, RRT and NE showed significant association with 28-day mortality (P<0.001). Here, ALB is linked to chronic kidney disease.